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Thiazolidinediones and Heart Failure: What You Need to Know About Fluid Retention Risks

Thiazolidinediones like pioglitazone and rosiglitazone help control blood sugar in type 2 diabetes but carry a serious risk of fluid retention that can trigger or worsen heart failure. Learn who’s at risk and what to do if you’re on these drugs.

Edward Jepson-Randall, Jan, 23 2026

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