Author: Edward Jepson-Randall

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Tramadol Seizure Risk: Who Is Most Vulnerable

Tramadol can cause seizures even at normal doses, especially in people with epilepsy, kidney issues, or those taking certain antidepressants. Learn who's most vulnerable and what to ask your doctor.

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Antihistamine Allergies: Understanding Cross-Reactivity and Symptoms to Watch For

Some people experience allergic reactions to antihistamines themselves, worsening symptoms instead of treating them. This rare condition involves paradoxical reactions where the medication triggers urticaria. Cross-reactivity between antihistamine classes complicates diagnosis. Symptoms include worsening hives, rash, or swelling. Proper diagnosis requires specialized testing and management by an allergist.

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How Liver and Kidney Changes Impact Drug Metabolism in Seniors

Older adults face liver and kidney changes that alter drug processing. These can cause dangerous side effects. Proper dose adjustments prevent hospitalizations. This article explains how aging affects drug metabolism and offers practical safety tips for seniors.

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Hip Labral Tears in Athletes: Diagnosis, Imaging, and Arthroscopy Explained

Hip labral tears are a leading cause of hip pain in athletes. Learn how imaging like MRA and arthroscopy diagnose and treat these injuries, why surgery isn't always needed, and what it takes to return to sport safely.

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Therapeutic Drug Monitoring for Generic NTI Drugs: Protecting Patients When Substitutions Go Wrong

Therapeutic drug monitoring protects patients on narrow therapeutic index (NTI) drugs when switching to generics. Even small changes in blood levels can cause harm-TDM ensures safety by measuring actual drug concentrations.

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IBD Biologics Explained: Anti-TNF, Anti-Integrin, and IL-12/23 Inhibitors

IBD biologics like anti-TNFs, vedolizumab, and IL-12/23 inhibitors offer targeted treatment for Crohn's and ulcerative colitis. Learn how they work, compare effectiveness, side effects, and costs, and understand what’s new in 2024.

Edward Jepson-Randall, Jan, 31 2026

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WHO Model Formulary: How International Standards Shape Global Access to Essential Generics

The WHO Model Formulary guides global access to affordable, life-saving generics. Used by over 150 countries, it ensures essential medicines meet strict safety, efficacy, and cost standards-saving millions of lives.

Edward Jepson-Randall, Jan, 29 2026

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How to Tell If Symptoms Are from Your Disease or Your Medication

Learn how to tell if new symptoms are from your illness or your medication. Use timing, dose changes, and symptom tracking to avoid misdiagnosis and unnecessary treatments.

Edward Jepson-Randall, Jan, 28 2026

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Analgesic Nephropathy: How NSAIDs Damage Kidneys and What Safer Pain Relief Looks Like

Analgesic nephropathy is a preventable kidney disease caused by long-term use of NSAIDs and acetaminophen. Learn how common painkillers damage kidneys, who's at risk, and what safer pain relief options actually work.

Edward Jepson-Randall, Jan, 27 2026

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Insurance Changes and Generic Switching: Navigating Formulary Updates in 2025

Learn how 2025 Medicare Part D formulary changes are forcing generic and biosimilar switches - and what you can do to protect your medication access and avoid costly surprises.

Edward Jepson-Randall, Jan, 24 2026